(19)

(11)

EP 1 086 373 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99927469.9 (22) Date of filing: 10.06.1999

(51) International Patent Classification (IPC)7: G01N 33/48, A61K 31/74, A61K 33/00, A01K 67/00 (86) International application number: PCT/US9913/210 (87) International publication number: WO 9964/857 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.06.1998 US 88800 P (71) Applicant: DUKE UNIVERSITY Durham,North Carolina 27708-0083 (US)	(72) Inventors: HAYNES, Barton, F. Durham, NC 27707 (US) PATEL, Dhavalkumar, D. Durham, NC 27712 (US) LEE, David West Roxbury, MA 02132 (US) (74) Representative: Walton, Seán Malcolm et al MEWBURN ELLIS,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)