(19)

(11)

EP 1 087 984 A2

(12)

(88) Date of publication A3: 15.06.2000 (43) Date of publication: 04.04.2001 Bulletin 2001/14 (21) Application number: 99953339.1 (22) Date of filing: 27.05.1999

(51) International Patent Classification (IPC)7: C07H 21/02, C07K 1/00, A61K 49/00, C12N 1/20 (86) International application number: PCT/US9911/704 (87) International publication number: WO 9961/452 (02.12.1999 Gazette 1999/48)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 28.05.1998 US 87079 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: PEARSON, Stewart, C. Berwyn, PA 19312 (US) KALLENDER, Howard Wayne, PA 19087 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)