(19)

(11)

EP 1 088 072 A2

(12)

(88) Date of publication A3: 06.04.2000 (43) Date of publication: 04.04.2001 Bulletin 2001/14 (21) Application number: 99931806.6 (22) Date of filing: 15.06.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12Q 1/68, C07K 14/47, C07K 16/18, A61K 38/17 (86) International application number: PCT/US9913/524 (87) International publication number: WO 9967/384 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 22.06.1998 US 102615 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto, CA 94304 (US)	(72) Inventors: WALKER, Michael G. Sunnyvale, CA 94089 (US) VOLKMUTH, Wayne Menlo Park, CA 94025 (US) KLINGLER, Tod, M. San Carlos, CA 94070 (US) SPRINZAK, Einat, A. Ramat-Gan (IL) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)