(19)
(11) EP 1 088 078 A2

(12)

(88) Date of publication A3:
29.06.2000

(43) Date of publication:
04.04.2001 Bulletin 2001/14

(21) Application number: 99929243.6

(22) Date of filing: 16.06.1999
(51) International Patent Classification (IPC)7: C12N 15/52, C07K 14/535, C07D 493/00
(86) International application number:
PCT/EP9904/171
(87) International publication number:
WO 9966/028 (23.12.1999 Gazette 1999/51)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
RO SI

(30) Priority: 18.06.1998 US 99504
24.09.1998 US 101631 P
05.02.1999 US 118906 P

(71) Applicants:
  • Novartis AG
    4058 Basel (CH)

    AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE 
  • Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.
    1230 Wien (AT)

    AT 

(72) Inventors:
  • SCHUPP, Thomas
    CH-4313 Möhlin (CH)
  • LIGON, James, Madison
    Apex, NC 27502 (US)
  • MOLNAR, Istvan
    Durham, NC 27705 (US)
  • ZIRKLE, Ross
    Raleigh, NC 27612 (US)
  • GÖRLACH, Jörn
    Durham, NC 27707 (US)
  • CYR, Devon
    Morrisville, NC 27560 (US)

(74) Representative: Becker, Konrad et al
Novartis AGCorporate Intellectual PropertyPatent- und Markenabteilung
4002 Basel
4002 Basel (CH)

   


(54) GENES FOR THE BIOSYNTHESIS OF EPOTHILONES