(19)

(11)

EP 1 088 079 A2

(12)

(88) Date of publication A3: 15.06.2000 (43) Date of publication: 04.04.2001 Bulletin 2001/14 (21) Application number: 99930298.7 (22) Date of filing: 15.06.1999

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/12, C12Q 1/68, C07K 16/40, C12Q 1/48, G01N 33/50, A61K 35/00, C12N 15/11 (86) International application number: PCT/US9913/533 (87) International publication number: WO 9966/051 (23.12.1999 Gazette 1999/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.06.1998 US 89520 P 28.08.1998 US 98265 P (71) Applicant: Sugen, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: PLOWMAN, Gregory San Carlos, CA 94070 (US) MARTINEZ, Ricardo Foster City, CA 94404 (US) ZHU, Yingfang San Bruno, CA 94066 (US) (74) Representative: Moon, Donald Keith et al BREWER & SONQuality HouseQuality CourtChancery Lane London WC2A 1HT London WC2A 1HT (GB)