(19)
(11) EP 1 088 088 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.11.2007 Bulletin 2007/47

(45) Mention of the grant of the patent:
17.10.2007 Bulletin 2007/42

(21) Application number: 98942283.7

(22) Date of filing: 28.08.1998
(51) International Patent Classification (IPC): 
C12N 9/10(2006.01)
C12P 7/64(2006.01)
 C12N 15/54(2006.01)
(86) International application number:
PCT/US1998/017883
(87) International publication number:
WO 1999/067403 (29.12.1999 Gazette 1999/52)

(54)

DIACYLGLYCEROL O-ACYLTRANSFERASE

DIACYLGLYZERIN O-ACYLTRANSFERASE

DIACYLGLYCEROL O-ACYLTRANSFERASE

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 24.06.1998 US 103754

(43) Date of publication of application:
04.04.2001 Bulletin 2001/14

(73) Proprietors:
  • The Regents of the University of California
    Oakland, CA 94607-5200 (US)
  • United States Government Represented by the Department of Veterans Affairs
    Washington DC 20420 (US)
  • The J. David Gladstone Institutes
    Irvine CA 92606 (US)

(72) Inventors:
  • FARESE, Robert, V., Jr.
    San Francisco, CA 64141-9100 (US)
  • CASES, Sylvaine
    San Francisco, CA 94141-9100 (US)
  • SMITH, Steven
    San Francisco, CA 94141-9100 (US)
  • ERICKSON, Sandra K.
    San Francisco, CA 94121 (US)

(74) Representative: Brasnett, Adrian Hugh et al
Mewburn Ellis LLP York House 23 Kingsway
London WC2B 6HP
London WC2B 6HP (GB)


(56) References cited: : 
   
  • WILSON R F ET AL: "RECENT DEVELOPMENTS IN THE MOLECULAR BIOCHEMISTRY AND GENETICS OF DIACYGLYCEROL ACYLTRANSFERASE FROM SOYBEAN" 1992 , SEED OILS FOR THE FUTURE, AOCS PRESS, CHAMPAIGN, IL, US, PAGE(S) 116-135 XP000884791 * the whole document *
  • DATABASE EMBL [Online] 24 September 1996 (1996-09-24) "mj94f05.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE:483777 5', mRNA sequence" Database accession no. AA061439 XP002267814
  • TABATA N ET AL: "Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus Lupulus" PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 46, no. 4, October 1997 (1997-10), pages 683-687, XP004293462 ISSN: 0031-9422
  • FARESE VF JR: "Acyl CoA:cholesterol acyltransferase genes and knockout mice" CURRENT OPINION IN LIPIDOLOGY, vol. 9, no. 2, April 1998 (1998-04), pages 119-123, XP008026803
  • KWANYUEN P ET AL: "SUBUNIT AND AMINO ACID COMPOSITION OF DIACYLGLYCEROL ACYLTRANSFERASE FROM GERMINATING SOYBEAN COTYLEDONS" BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1039, no. 1, 31 May 1990 (1990-05-31), pages 65-72, XP000884516 ISSN: 0006-3002
  • KWANYUEN P; WILSON RF: "N-terminal sequence of the 40.8 kDa subunit of diacylglycerol acyltransferase from soybean" PLANT PHYSIOLOGY, vol. 96, no. 1 SUPPL, May 1991 (1991-05), page 125 XP002268383 ISSN: 0032-0889
  • CASES S ET AL: "Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 22, 27 October 1998 (1998-10-27), pages 13018-13023, XP002122745 ISSN: 0027-8424
  • FRENTZEN M (REPRINT): "Acyltransferases from basic science to modified seed oils" FETT - LIPID, WILEY-VCH VERLAG,WEINHEIM, DE, vol. 100, no. 4/5, May 1998 (1998-05), pages 161-166, XP002122744 ISSN: 0931-5985
  • CASES S. et al., "Cloning and Expression of a Candidate Gene for Diacylglyceral Acyltransferase", FASEB J., 20 March 1998, Vol. 12, No. 5, page A814, Abstract 4718, XP002915658
  • ANDERSSON M. et al., "Purification of Diacylglycerol: Acyltransferase from Rat Liver to Near Homogeneity", JOURNAL OF LIPID RESEARCH, 1994, Vol. 35, pages 535-545, XP002915656
  • KATAVIC V. et al., "Alteration of Seed Fatty Acid Composition by an Ethyl Methanesulfonate-Induced Mutation in Arabidopsis Thaliana Affecting Diacylglycerol Acyltransferase Activity", PLANT PHYSIOLOGY, 1995, Vol. 108, pages 399-409, XP002915657
   
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