(19)

(11)

EP 1 088 107 A1

(12)

(43) Date of publication: 04.04.2001 Bulletin 2001/14 (21) Application number: 99931897.5 (22) Date of filing: 23.06.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34 (86) International application number: PCT/US9914/347 (87) International publication number: WO 9967/426 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.06.1998 US 90348 P (71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM Austin, Texas 78701 (US)	(72) Inventors: REED-GITOMER, Berenice, Y. Dallas, TX 75205 (US) PAK, Charles, Y., C. Dallas, TX 75230 (US) (74) Representative: Glawe, Delfs, Moll & Partner  PatentanwälteRothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)