(19)

(11)

EP 1 088 128 A1

(12)

(43) Date of publication: 04.04.2001 Bulletin 2001/14 (21) Application number: 99922991.7 (22) Date of filing: 12.05.1999

(51) International Patent Classification (IPC)7: D06M 16/00 // D06M101:12 (86) International application number: PCT/US9910/496 (87) International publication number: WO 9960/200 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.05.1998 US 82218 28.09.1998 US 161824 (71) Applicant: Novo Nordisk Biochem North America, Inc. Franklinton, NC 27525 (US)	(72) Inventors: MCDEVITT, Jason, Patrick Wake Forest, NC 27587 (US) WINKLER, Jakob DK-2300 Kobenhavn S (DK) (74) Representative: Stahr, Pia et al Novo Nordisk A/S,Enzyme Business Patents,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)