(19)

(11)

EP 1 089 750 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99930491.8 (22) Date of filing: 21.06.1999

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 38/07, A61K 31/66, C07K 5/00 (86) International application number: PCT/US9913/961 (87) International publication number: WO 9966/945 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.06.1998 US 90497 P 15.07.1998 US 92917 P 06.08.1998 GB 9817170 02.09.1998 GB 9819126 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventor: RESZKA, Alfred, A. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James  European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)