(19)

(11)

EP 1 089 756 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99925696.9 (22) Date of filing: 20.05.1999

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/38, A61K 39/02, A61K 49/00, G01N 31/00, G01N 33/48, C12N 1/12, C12N 1/20, C07K 1/00, C07K 14/00, C07K 17/00 (86) International application number: PCT/US9911/158 (87) International publication number: WO 9961/048 (02.12.1999 Gazette 1999/48)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 22.05.1998 US 86456 P 01.04.1999 US 127415 P (71) Applicants: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US) Smithkline Beecham Biologicals 1330 Rixensart (BE)	(72) Inventors: PARENTI, Dennis Lansdale, PA 19446 (US) LOBET, Yves B-1330 Rixensart (BE) GILLET, Marc B-1330 Rixensart (BE) (74) Representative: Privett, Kathryn Louise et al SmithKline Beecham plc,Corporate Intellectual Property,Two New Horizons Court - 2/NHC/1,Great West Road Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)