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(11)

EP 1 089 969 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99928821.0 (22) Date of filing: 21.06.1999

(51) International Patent Classification (IPC)7: C07C 381/00, A61K 31/095, A61L 2/18 (86) International application number: PCT/US9913/963 (87) International publication number: WO 9967/210 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: DE ES FR GB IE IT NL SE (30) Priority: 23.06.1998 US 103227 (71) Applicant: DUKE UNIVERSITY MEDICAL CENTER Durham, NC 27710 (US)	(72) Inventors: TOONE, Eric, J. Durham, NC 27705 (US) STAMLER, Jonathan, S. Chapel Hill, NC 27514 (US) (74) Representative: Kirkham, Nicholas Andrew et al Graham Watt & Co.,Riverhead Sevenoaks,Kent TN13 2BN Sevenoaks,Kent TN13 2BN (GB)