(19)

(11)

EP 1 089 981 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99937164.4 (22) Date of filing: 21.06.1999

(51) International Patent Classification (IPC)7: C07D 243/24, A61K 31/55, C07D 243/14, C07D 243/12, C07D 221/22, C07D 223/18, C07D 471/06, C07D 409/12, C07D 401/04, C07D 417/04, C07D 409/04 // (C07D471/06, 223:00), C07D221:00 (86) International application number: PCT/US9914/007 (87) International publication number: WO 9967/220 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.06.1998 US 102728 (71) Applicants: Elan Pharmaceuticals, Inc. South San Francisco, CA 94080 (US) ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: AUDIA, James, E. Indianapolis, IN 46278 (US) THOMPSON, Richard, C. Frankfort, IN 46041 (US) WILKIE, Stephen, C. Indianapolis, IN 46268 (US) BRITTON, Thomas, C. Carmel, IN 46033 (US) PORTER, Warren, J. Indianapolis, IN 46260 (US) HUFFMAN, George, W. Carmel, IN 46032 (US) LATIMER, Lee, H. Oakland, CA 94618 (US) (74) Representative: Adams, Nicola  Abel & Imray,20 Red Lion Street London WC1R 4PQ London WC1R 4PQ (GB)