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(11)

EP 1 089 989 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99930614.5 (22) Date of filing: 23.06.1999

(51) International Patent Classification (IPC)7: C07D 277/00 (86) International application number: PCT/US9914/233 (87) International publication number: WO 9967/230 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.06.1998 US 90421 P (71) Applicants: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US) TANABE SEIYAKU CO., LTD. Chuo-ku,Osaka-shi,Osaka 541-8505 (JP)

(72) Inventors: BLINN, James, R. Portage, MI 49024 (US) CHRUSCIEL, Robert, A. Portage, MI 49024 (US) FISHER, Jed, F. Kalamazoo, MI 49008 (US) TANIS, Steven, P. Kalamazoo, MI 49002 (US) THOMAS, Edward, William Kalamazoo, MI 49008 (US) LOBL, Thomas, J. South San Francisco, CA 94080 (US) TEEGARDEN, Bradley, R. San Diego, CA 92131 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)