(19)

(11)

EP 1 090 009 A2

(12)

(88) Date of publication A3: 30.03.2000 (43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99926157.1 (22) Date of filing: 03.06.1999

(51) International Patent Classification (IPC)7: C07D 495/04, C07D 498/04, C07D 513/04, C07D 471/04, C07D 491/04, A61K 31/44, A61K 31/50, A61K 31/505 // (C07D495/04, 333:00), C07D239:00,(C07D495/04, 333:00), C07D221:00,(C07D498/04, 263:00), C07D221:00,(C07D513/04, 277:00), C07D221:00, C07D471:04, C07D235:00, C07D221:00, C07D495:04, C07D333:00 (86) International application number: PCT/US9912/419 (87) International publication number: WO 9962/908 (09.12.1999 Gazette 1999/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: RO SI (30) Priority: 04.06.1998 US 90701 (71) Applicant: ABBOTT LABORATORIES Abbott Park,IL 60064-6050 (US)

(72) Inventors: STEWART, Andrew, O. Libertyville, IL 60048 (US) BOYD, Steven, A. Mundelein, IL 60060 (US) ARENDSEN, David, L. Libertyville, IL 60048 (US) BHATIA, Pramila Libertyville, IL 60048 (US) CONDROSKI, Kevin, R. Evanston, IL 60202 (US) FREEMAN, Jennifer, C. Grayslake, IL 60030 (US) GUNAWARDANA, Indrani, W. Libertyville, IL 60048 (US) ZHU, Gui-Dong Gurnee, IL 60031 (US) LARTEY, Kraig Waukegan, IL 60085 (US) MCCARTY, Catherine, M. Brookline, MA 02446 (US) MORT, Nicholas, A. Waukegan, IL 60085 (US) PATEL, Meena V. Chicago, IL 60661 (US) STAEGER, Michael, A. Greenfield, WI 53221 (US) STOUT, David, M. Libertyville, IL 60048 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)