(19)

(11)

EP 1 090 037 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99955481.9 (22) Date of filing: 08.06.1999

(51) International Patent Classification (IPC)7: C07K 16/00, A61K 39/395, A61K 47/48 // (C07K16/22, 16:24, 16:28) (86) International application number: PCT/GB9901/800 (87) International publication number: WO 9964/460 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.06.1998 GB 9812545 (71) Applicant: CELLTECH THERAPEUTICS LIMITED Slough,Berkshire SL1 4EN (GB)	(72) Inventors: CHAPMAN, Andrew Paul Middlesex TW12 3DL (GB) KING, David John Foster City, CA 94404 (US) (74) Representative: Mercer, Christopher Paul  Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)