(19)

(11)

EP 1 090 126 A1

(12)

(43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99916080.7 (22) Date of filing: 22.04.1999

(51) International Patent Classification (IPC)7: C12N 15/53, C12N 9/04, C12N 1/21, C12P 13/22, C12P 1/04 (86) International application number: PCT/NL9900/232 (87) International publication number: WO 9955/877 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB IT LI NL PT SE (30) Priority: 24.04.1998 DE 19818541 (71) Applicants: Holland Sweetener Company V.o.F. 6167 RA Geleen (NL) FORSCHUNGSZENTRUM JÜLICH GMBH 52425 Jülich (DE) DSM Biotech GmbH 52428 Jülich (DE)	(72) Inventors: KRAEMER, Marco D-52428 Jülich (DE) KARUTZ, Martin NL-6137 JE Sittard (NL) SPRENGER, Georg D-52428 Jülich (DE) SAHM, Hermann D-52428 Jülich (DE) (74) Representative: den Hartog, Jeroen H.J. et al DSM Patents & TrademarksOffice GeleenP.O. Box 9 6160 MA Geleen 6160 MA Geleen (NL)