ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY....................................................*JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/01090133CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120091125W173deBibliographieenBibliographyfrBibliographieEP99926204.1199906212001011920030415enenen10205019980622US2009112520094820010411200115200908122009332008041120091125200948C12N 15/82 20060101AFI20080423BHEP C12N 15/12 20060101ALI20080423BHEP A61K 38/17 20060101ALI20080423BHEP deHERSTELLUNG VON IL-10 IN EINEN PFLANZENBIOREAKTOR AUS PFLANZEN, DIE NICHT ZUR ERNÄHRUNG VERWENDET WERDENenPRODUCTION OF IL-10 IN NON-FOOD CROP PLANT BIOREACTORfrPRODUCTION DE IL-10 DANS UN BIOREACTEUR DE PLANTES CULTIVEES NON ALIMENTAIRESWO-A-93/03161CA-A- 2 188 220SPURGEON D.: "Tobacco could be used to produce interleukin 10" BRITISH MEDICAL JOURNAL, vol. 319, no. 7203, 17 July 1999 (1999-07-17), pages 143-143, XP002127522LEVINE ET AL.: "High level expression and refolding of mouse interleukin 4 synthesized in E. coli." J. BIOL. CHEM., vol. 270, no. 13, 31 March 1995 (1995-03-31), pages 7445-7452,SYTO ET AL.: "Structural and biological stability of the human interleukin 10 homodimer" BIOCHEMISTRY, vol. 37, 11 July 1998 (1998-07-11), pages 16943-16951,VIEIRA ET AL.: "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI" PNAS, vol. 88, February 1991 (1991-02), pages 1172-1176,ZDAVOV ET AL.: "Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma" CURRENT BIOLOGY-STRUCTURE, vol. 3, 15 June 1995 (1995-06-15), pages 591-601,WERNER ET AL.: "Appropriate mammalian expression systems for biopharmaceuticals" ARZNEIM. -FORSCH./DRUG RES., vol. 48, no. II-8, 1998, pages 870-880,EDELBAUM ET AL.: "Expression of active human interferon-beta in transgenic plants" J. INTERFERON RES., vol. 12, 1992, pages 449-453,MENASSA ET AL.: "Therapeutic effectiveness of orally administered transgenic low-alkaloid tobacco expressing human interleukin-10 in a mouse model of colitis" PLANT BIOTECHNOLOGY JOURNAL, vol. 5, 2006, pages 50-59,BRANDLE, Jim17 Willingdon AvenueLondon, Ontario N6A 3Y5CADAVIES, Peter, L.100 Dickens DriveKingston, Ontario K7M 2M8CAKENWARD, Kimberley, D.17-152 Albert StreetLondon, Ontario N6A 1M1CAMENASSA, Rima733 Algoma AvenueLondon, Ontario N5X 1W4CAJEVNIKAR, Tony213 Hunt Club DriveLondon, Ontario N6H 3Y8CADELOVITCH, Terry1560 Gloucester RoadLondon, Ontario N6G 2S6CAHER MAJESTY THE QUEEN IN RIGHT OF CANADA, as represented by the Minister of Agriculture and Agri-Food10017790P27874/LMM/RMCPest Management Research Centre, 1391 Sanford Street London,Ontario N5V 4T3CAQueen's University02207131P27874/LMM/RMCKingston, Ontario K7L 3N6CAThe John P. Robarts Research Institute02470270P27874/LMM/RMC100 Perth Drive, P.O. Box 515London, Ontario N6A 5K8CALondon Health Sciences Center10301230P27874/LMM/RMC375 South Street, Room C215 Nurses' Residence South Street Hospital P.O.Box 5375London, Ontario, N6A 4G5CAMain, Malcolm Charleset al00122921Murgitroyd & Company Scotland House 165-169 Scotland StreetGlasgow G5 8PLGBATBECHCYDEDKESFIFRGBGRIEITLILUMCNLPTSECA199900057719990621enWO199906740119991229199952