(19)
(11) EP 1 091 726 A2

(12)

(88) Date of publication A3:
18.05.2000

(43) Date of publication:
18.04.2001 Bulletin 2001/16

(21) Application number: 99925585.4

(22) Date of filing: 11.05.1999
(51) International Patent Classification (IPC)7A61K 7/00
(86) International application number:
PCT/US9910/287
(87) International publication number:
WO 9958/096 (18.11.1999 Gazette 1999/46)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 11.05.1998 US 85037 P
21.08.1998 US 97384 P
12.11.1998 US 108037 P

(71) Applicant: EntreMed, Inc.
Rockville,Maryland 20850 (US)

(72) Inventors:
  • SHAH, Jamshed, H.
    Columbia, MD 21045 (US)
  • SWARTZ, Glenn, M.
    Mt. Airy, MD 21771 (US)
  • PAPATHANASSIU, Adonia E.
    Silver Springs, MD 20910 (US)
  • FOGLER, William, E.
    Rockville, MD 20850 (US)
  • MADSEN, John, W.
    Knoxville, MD 21758 (US)
  • GREEN, Shawn, J.
    Vienna, VA 22182 (US)

(74) Representative: Elsy, David 
Withers & Rogers,Goldings House,2 Hayslane
London SE1 2HW
London SE1 2HW (GB)

   


(54) ANALOGS OF 2-PHTHALIMIDINOGLUTARIC ACID AND THEIR USE AS INHIBITORS OF ANGIOGENESIS