(19)

(11)

EP 1 091 958 A1

(12)

(43) Date of publication: 18.04.2001 Bulletin 2001/16 (21) Application number: 99932772.9 (22) Date of filing: 30.06.1999

(51) International Patent Classification (IPC)7: C07D 405/12, A61K 31/445 (86) International application number: PCT/EP9904/543 (87) International publication number: WO 0001/692 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: RO SI (30) Priority: 02.07.1998 GB 9814316 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventor: JACEWICZ, Victor Witold Near Leigh,Tonbridge,Kent TN11 9AN (GB) (74) Representative: West, Vivien  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)