(19)
(11) EP 1 091 960 A1

(12)

(43) Date of publication:
18.04.2001 Bulletin 2001/16

(21) Application number: 99931893.4

(22) Date of filing: 24.06.1999
(51) International Patent Classification (IPC)7: C07D 475/02, C07D 473/04, C07D 513/04, C07D 239/96, C07D 217/24, C07D 401/14, A61K 31/505, A61K 31/52
// (C07D513/04, 285:00), C07D239:00
(86) International application number:
PCT/US9914/320
(87) International publication number:
WO 0000/491 (06.01.2000 Gazette 2000/01)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 29.06.1998 US 107026

(71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Oakland, California 94607-5200 (US)

(72) Inventors:
  • CARSON, Dennis A.
    Del Mar, CA 92014 (US)
  • COTTOM, Howard B.
    Escondido, CA 92025 (US)
  • CHAO, Qi
    San Diego, CA 92122 (US)

(74) Representative: Goldin, Douglas Michael et al
J.A. KEMP & CO.14 South SquareGray's Inn
London WC1R 5LX
London WC1R 5LX (GB)

   


(54) BIFUNCTIONAL ANTAGONISTS OF CYTOKINE-SENSITIVE PROTEIN KINASE ACTIVATION CASCADES AND METHODS FOR USE AS ANTI-INFLAMMATORY AGENTS