(19)

(11)

EP 1 092 041 A1

(12)

(43) Date of publication: 18.04.2001 Bulletin 2001/16 (21) Application number: 00919763.3 (22) Date of filing: 27.03.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, C12N 15/09, C07H 21/02, A61K 39/00 (86) International application number: PCT/US0008/245 (87) International publication number: WO 0058/517 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 US 276860 14.06.1999 US 332835 (71) Applicant: Diversa Corporation San Diego, CA 92121 (US)	(72) Inventors: SHORT, Jay, M. Rancho Santa Fe, CA 92067-7214 (US) DJAVAKHISHVILI, Tsotne, David San Diego, CA 92122 (US) FREY, Gerhard, Johann San Diego, CA 92129 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)