(19)

(11)

EP 1 093 367 A1

(12)

(43) Date of publication: 25.04.2001 Bulletin 2001/17 (21) Application number: 99930779.6 (22) Date of filing: 24.06.1999

(51) International Patent Classification (IPC)7: A61K 31/34, A61K 31/36, A61K 31/38, A61K 31/39, A61K 31/41, A61K 31/415, A61K 31/425, A61K 31/445, A61K 31/505, A61K 31/535, C07D 215/14, C07D 231/12, C07D 263/32, C07D 277/10, C07D 277/66, C07D 285/06, C07D 307/80, C07D 317/50, C07D 319/20, C07D 333/78, C07D 401/12 (86) International application number: PCT/US9914/561 (87) International publication number: WO 9966/925 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 24.06.1998 US 90493 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HALBERT, Stacie, Marie Harleysville, PA 19438 (US) MICHAUD, Evelyne F-45015 Paris (FR) THOMPSON, Scott, Kevin Phoenixville, PA 19460 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Rutter, Keith, Dr. et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)