INDOLE AND TETRAHYDROISOQUINOLINE CONTAINING $g(a)-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS - Patent 1093368

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EP 1 093 368 A1

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(43)	Date of publication:
	25.04.2001 Bulletin 2001/17

(21)	Application number: 99927189.3

(22)	Date of filing: 03.06.1999

(51)	International Patent Classification (IPC)⁷: A61K 31/405, A61K 31/41, A61K 31/47, C07D 217/12, C07D 217/16, C07D 249/08, C07D 271/06, C07D 271/10

(86)	International application number:
	PCT/US9912/352

(87)	International publication number:
	WO 9962/514 (09.12.1999 Gazette 1999/49)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

03.06.1998 US

(60)	Divisional application:
	01200500.5

(71)	Applicants:
	Cortech Inc. Bedminster, NJ 07921 (US) Ono Pharmaceutical Co. Osaka 541-0045 (JP)

(72)	Inventors:
	SPRUCE, Lyle Chula Vista, CA 91910 (US) GYORKOS, Albert Westminster, CO (US)

(74)	Representative: Mallalieu, Catherine Louise et al
	D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)

(54)	INDOLE AND TETRAHYDROISOQUINOLINE CONTAINING $g(a)-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS