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(11)

EP 1 093 516 A2

(12)

(88) Date of publication A3: 29.06.2000 (43) Date of publication: 25.04.2001 Bulletin 2001/17 (21) Application number: 99931753.0 (22) Date of filing: 06.07.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/19, C12N 15/57, C12N 15/62, C07K 16/18, C07K 16/28, C07K 16/24, C07K 16/40, C12Q 1/68, G01N 33/566, G01N 33/68, A61K 38/17, A61K 38/19, A61K 38/48 (86) International application number: PCT/US9912/366 (87) International publication number: WO 0001/817 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.07.1998 US 110938 13.07.1998 US 114466 23.07.1998 US 93897 P 12.08.1998 US 132968 18.08.1998 US 136214 11.09.1998 US 99999 P (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)

(72) Inventors: BATES, Elizabeth, Esther, Mary F-69001 Lyon (FR) LEBECQUE, Serge, J., E. F-69380 Civrieux d'Azergue (FR) MURPHY, Erin, E. Palo Alto, CA 94301 (US) MATTSON, Jeanine, D. San Francisco, CA 94114 (US) GORMAN, Daniel, M. Newark, CA 94560 (US) HEDRICK, Joseph, A. New Jersey, NJ 08882 (US) WANG, Luquan East Brunswick, NJ 08816 (US) ZLOTNIK, Albert Palo Alto, CA 94306 (US) MURGOLO, Nicholas, J. Millington, NJ 07946 (US) GREENE, Jonathan, R. South Orange, NJ 07079 (US) JOHNSTON, James, A. Los Gatos, CA 95032 (US) BAZAN, Jose, Fernando Menlo Park, CA 94025 (US) MAHONY, Daniel New York, NY 10016 (US) LEES, Emma, M. San Francisco, CA 94115 (US) (74) Representative: Almond-Martin, Carol et al Ernest Gutmann - Yves Plasseraud S.A.3, rue Chauveau-Lagarde 75008 Paris 75008 Paris (FR)