(19)

(11)

EP 1 095 011 A1

(12)

(43) Date of publication: 02.05.2001 Bulletin 2001/18 (21) Application number: 99932334.8 (22) Date of filing: 07.07.1999

(51) International Patent Classification (IPC)7: C07C 229/42, C07C 229/76, C07D 219/04, C07D 311/88, C07D 491/052 (86) International application number: PCT/US9915/366 (87) International publication number: WO 0001/663 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.07.1998 US 91944 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: CHAN, George, Wai-Kin Wynnewood, PA 19096 (US) HERTZBERG, Robert, P. Downington, PA 19335 (US) (74) Representative: West, Vivien et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)