(19)

(11)

EP 1 095 060 A1

(12)

(43) Date of publication: 02.05.2001 Bulletin 2001/18 (21) Application number: 99933694.4 (22) Date of filing: 02.07.1999

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 16/28, C12N 1/21, C12N 5/10, C12N 15/12 (86) International application number: PCT/US9915/169 (87) International publication number: WO 0001/728 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.07.1998 US 109864 (71) Applicant: Human Genome Sciences Rockville,Maryland 20850 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) NI, Jian Rockville, MD 20853 (US) GENTZ, Reiner, L. Rockville, MD 20850 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)