(19)

(11)

EP 1 095 133 A1

(12)

(43) Date of publication: 02.05.2001 Bulletin 2001/18 (21) Application number: 99935377.4 (22) Date of filing: 30.06.1999

(51) International Patent Classification (IPC)7: C12N 9/00 (86) International application number: PCT/US9914/890 (87) International publication number: WO 0001/801 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.07.1998 US 91680 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HENSLEY, Curtis, Preston Groton, CT 06340 (US) PEARCE, Kenneth, H. Phoenixville, PA 19426 (US) SOSSONG, Thomas, M. Royersford, PA 19468 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)