(19)

(11)

EP 1 095 138 A2

(12)

(88) Date of publication A3: 20.04.2000 (43) Date of publication: 02.05.2001 Bulletin 2001/18 (21) Application number: 99934633.1 (22) Date of filing: 08.07.1999

(51) International Patent Classification (IPC)7: C12N 15/11 (86) International application number: PCT/EP9904/804 (87) International publication number: WO 0003/004 (20.01.2000 Gazette 2000/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV RO SI (30) Priority: 09.07.1998 EP 98112653 25.03.1999 US 126200 P (71) Applicant: Boehringer Ingelheim Pharma KG 55218 Ingelheim am Rhein (DE)	(72) Inventors: FECHTELER, Katja D-65197 Wiesbaden (DE) MENDLA, Klaus D-55218 Ingelheim am Rhein (DE) SAUER, Nicole D-42489 Wuelfrath (DE) (74) Representative: Laudien, Dieter, Dr. et al Boehringer Ingelheim GmbH,B Patent 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)