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(11)

EP 1 096 927 A1

(12)

(43) Date of publication: 09.05.2001 Bulletin 2001/19 (21) Application number: 99934107.6 (22) Date of filing: 16.07.1999

(51) International Patent Classification (IPC)7: A61K 31/135, A61K 31/415, A61K 31/495, A01N 43/60 (86) International application number: PCT/US9916/153 (87) International publication number: WO 0003/701 (27.01.2000 Gazette 2000/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.07.1998 US 93013 P (71) Applicant: Massachusetts Institute of Technology Cambridge, MA 02142-1324 (US)	(72) Inventors: WURTMAN, Judith, J. Boston, MA 02116 (US) WURTMAN, Richard, J. Boston, MA 02116 (US) (74) Representative: Lamb, Martin John Carstairs  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)