(19)

(11)

EP 1 097 129 A1

(12)

(43) Date of publication: 09.05.2001 Bulletin 2001/19 (21) Application number: 99936567.9 (22) Date of filing: 19.07.1999

(51) International Patent Classification (IPC)7: C07C 311/20, C07C 233/80, C07C 235/56, C07D 261/18, C07D 333/34, C07D 333/24, C07C 233/65, C07C 235/42, C07D 213/82, A61K 31/18, A61K 31/27, A61K 31/38, A61K 31/42, A61K 31/44 (86) International application number: PCT/EP9905/131 (87) International publication number: WO 0005/201 (03.02.2000 Gazette 2000/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.07.1998 US 120017 (71) Applicants: Novartis AG 4058 Basel (CH) BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE CY  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. 1230 Wien (AT) AT	(72) Inventors: FINK, Cynthia, Anne Lebanon, NJ 08833 (US) KSANDER, Gary, Michael Milford, NJ 08848 (US) KUKKOLA, Paivi, Jaana Whitehouse Station, NJ 08889 (US) WALLACE, Eli, Melville Chapel Hill, NC 27516 (US) (74) Representative: Becker, Konrad  Novartis AGCorporate Intellectual PropertyPatent- und Markenabteilung 4002 Basel 4002 Basel (CH)