(19)

(11)

EP 1 097 166 A2

(12)

(88) Date of publication A3: 20.04.2000 (43) Date of publication: 09.05.2001 Bulletin 2001/19 (21) Application number: 99944996.0 (22) Date of filing: 20.07.1999

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/475, C07K 16/00, C07K 16/28, C12N 5/10, C12N 15/12, C12N 15/63, G01N 33/53, G01N 33/567 (86) International application number: PCT/US9916/471 (87) International publication number: WO 0003/687 (27.01.2000 Gazette 2000/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.07.1998 US 93486 P 13.08.1998 US 96655 P (71) Applicant: Elan Pharmaceuticals, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: FORSAYETH, John, R. San Francisco, CA 94110 (US) ZHAO, Byron, B. Palo Alto, CA 94303 (US) CHAVEZ, Raymond, A. Alameda, CA 94501 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)