USURPIN, A MAMMALIAN DED-CASPASE HOMOLOGUE THAT PRECLUDES CASPASE-8 RECRUITMENT AND ACTIVATION BY THE CD-95 (FAS, APO-1) RECEPTOR COMPLEX - Patent 1097226

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EP 1 097 226 A1

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(43)	Date of publication:
	09.05.2001 Bulletin 2001/19

(21)	Application number: 99927635.5

(22)	Date of filing: 07.07.1999

(51)	International Patent Classification (IPC)⁷: C12N 15/57, C12N 5/10, C12N 1/21, C12N 9/64, C07K 16/40, G01N 33/50

(86)	International application number:
	PCT/CA9900/615

(87)	International publication number:
	WO 0003/023 (20.01.2000 Gazette 2000/03)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

08.07.1998 US 92005 P

(71)	Applicant: Merck Frosst Canada & Co.
	Kirkland, Quebec H9H 3L1 (CA)

(72)	Inventors:
	NICHOLSON, Donald, W. Kirkland, Quebec H9H 3L1 (CA) RASPER, Dita, M. Kirkland, Quebec H9H 3L1 (CA) XANTHOUDAKIS, Steve Kirkland, Quebec H9H 3L1 (CA) ROY, Sophie Kirkland, Quebec H9H 3L1 (CA)

(74)	Representative: Horgan, James Michael Frederic
	Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)

(54)	USURPIN, A MAMMALIAN DED-CASPASE HOMOLOGUE THAT PRECLUDES CASPASE-8 RECRUITMENT AND ACTIVATION BY THE CD-95 (FAS, APO-1) RECEPTOR COMPLEX