(19)

(11)

EP 1 098 653 A2

(12)

(88) Date of publication A3: 09.11.2000 (43) Date of publication: 16.05.2001 Bulletin 2001/20 (21) Application number: 99933540.9 (22) Date of filing: 09.07.1999

(51) International Patent Classification (IPC)7: A61K 31/57, A61K 31/565 // (A61K31/57, 31:565) (86) International application number: PCT/US9914/129 (87) International publication number: WO 0003/678 (27.01.2000 Gazette 2000/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.07.1998 US 93171 P 09.10.1998 US 103699 P 30.03.1999 US 126824 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventor: DE KONING GANS, Hendrik, J. Kalamazoo, MI 49006 (US) (74) Representative: Perry, Robert Edward et al GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)