(19)

(11)

EP 1 098 877 A1

(12)

(43) Date of publication: 16.05.2001 Bulletin 2001/20 (21) Application number: 99920192.4 (22) Date of filing: 29.04.1999

(51) International Patent Classification (IPC)7: C07D 207/40, A61K 7/06, A61K 31/74 (86) International application number: PCT/US9909/430 (87) International publication number: WO 9967/216 (29.12.1999 Gazette 1999/52)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.06.1998 US 103386 24.06.1998 US 103856 24.06.1998 US 104309 (71) Applicant: ISP INVESTMENTS INC. Wilmington,Delaware 19801 (US)	(72) Inventors: ULMER, Herbert, W. Hoboken, NJ 07030 (US) GILLECE, Timothy Pompton Plains, NJ 07444 (US) KATIRGIS, John, A. West Caldwell, NJ 07006 (US) FOLTIS, Linda, C. Nutley, NJ 07110 (US) BLAINE, April Highland Lakes, NJ 07422 (US) (74) Representative: Harrison, David Christopher et al MEWBURN ELLISYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)