(19)

(11)

EP 1 098 973 A1

(12)

(43) Date of publication: 16.05.2001 Bulletin 2001/20 (21) Application number: 99934930.1 (22) Date of filing: 21.07.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 9/12, C07K 16/40, C12Q 1/48 (86) International application number: PCT/GB9902/379 (87) International publication number: WO 0005/365 (03.02.2000 Gazette 2000/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.07.1998 GB 9816030 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventor: DUCKWORTH, David M.,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)