(19)

(11)

EP 1 098 976 A2

(12)

(88) Date of publication A3: 27.04.2000 (43) Date of publication: 16.05.2001 Bulletin 2001/20 (21) Application number: 99935630.6 (22) Date of filing: 16.07.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, G01N 33/50, G01N 33/74 (86) International application number: PCT/US9916/122 (87) International publication number: WO 0004/152 (27.01.2000 Gazette 2000/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.07.1998 US 93239 P 14.09.1998 US 100243 P (71) Applicant: UNIVERSITY OF ROCHESTER Rochester, NY 14627-0140 (US)	(72) Inventor: CHANG, Chawnshang,University of Rochester Rochester, NY 14642 (US) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)