(19)

(11)

EP 1 100 412 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99935819.5 (22) Date of filing: 23.07.1999

(51) International Patent Classification (IPC)7: A61F 2/16 (86) International application number: PCT/US9916/547 (87) International publication number: WO 0004/849 (03.02.2000 Gazette 2000/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.07.1998 US 93994 P (71) Applicant: Johns Hopkins University School of Medicine Baltimore, MD 21202 (US)	(72) Inventor: AYOUB, Adham Cairo (EG) (74) Representative: Flint, Adam  W.H. Beck, Greener & Co.,7 Stone Buildings,Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)