(19)

(11)

EP 1 100 495 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99937585.0 (22) Date of filing: 28.07.1999

(51) International Patent Classification (IPC)7: A61K 31/34, A61K 31/38, A61K 31/40, A61K 31/42, A61K 31/44, A61K 31/47, A61K 31/135, A61K 31/405, C07C 211/00, C07D 211/06, C07D 491/107 (86) International application number: PCT/US9917/117 (87) International publication number: WO 0006/153 (10.02.2000 Gazette 2000/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.07.1998 US 94405 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19101 (US)	(72) Inventors: BONDINELL, William, E. Wayne, PA 19087 (US) NEEB, Michael, J. King of Prussia, PA 19406 (US) KU, Thomas, W. Dresher, PA 19025 (US) (74) Representative: Blakey, Alison Jane  GlaxoSmithKline,Two New Horizons Court Brentford,Middlesex TW8 9EP Brentford,Middlesex TW8 9EP (GB)