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(11)

EP 1 100 544 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99933855.1 (22) Date of filing: 08.07.1999

(51) International Patent Classification (IPC)7: A61K 48/00, A01N 63/00, C12N 15/63, C12N 15/85, C12N 15/86, C07H 21/04 (86) International application number: PCT/US9915/594 (87) International publication number: WO 0004/927 (03.02.2000 Gazette 2000/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.07.1998 US 93965 P (71) Applicants: Alleghney University of the Health Sciences Philadelphia, PA 19102-1192 (US) Halpern, Michael S. West Newton, MA 02465 (US) England, James M. Media, PA 19063 (US)	(72) Inventors: HALPERN, Michael, S. West Newton, MA 02465 (US) ENGLAND, James, M. Media, PA 19063 (US) (74) Representative: Shah, Punita et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)