(19)

(11)

EP 1 100 826 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99937584.3 (22) Date of filing: 28.07.1999

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 16/28, C12N 5/10, C12N 15/12 (86) International application number: PCT/US9917/116 (87) International publication number: WO 0006/601 (10.02.2000 Gazette 2000/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.07.1998 US 94702 P (71) Applicant: Aventis Pharmaceuticals Products Inc. Bridgewater, NJ 08807-0800 (US)	(72) Inventors: YU, Kin, T. Limerick, PA 19468 (US) LABAUDINIERE, Richard, F. Collegeville, PA 19426 (US) THROWER, Larry, W. Royersford, PA 19468 (US) (74) Representative: Jones, Stephen Anthony  AdamsonJonesBroadway Business Centre32a Stoney Street Nottingham NG1 1LL Nottingham NG1 1LL (GB)