(19)

(11)

EP 1 100 881 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99937422.6 (22) Date of filing: 23.07.1999

(51) International Patent Classification (IPC)7: C12N 9/02, C12N 15/00, C07H 21/02, C07H 21/04 (86) International application number: PCT/US9916/746 (87) International publication number: WO 0005/350 (03.02.2000 Gazette 2000/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.07.1998 US 94012 P (71) Applicant: WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION Pullman, WA 99164-1802 (US)	(72) Inventors: LEWIS, Norman, G. Pullman, WA 99163 (US) KASAHARA, Hiroyuki Pullman, WA 99163 (US) GANG, David, R. Ann Arbor, MI 48108 (US) DAVIN, Laurence, B. Pullman, WA 99163 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)