(19)

(11)

EP 1 100 887 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99938885.3 (22) Date of filing: 28.07.1999

(51) International Patent Classification (IPC)7: C12N 15/09, C12N 15/63 (86) International application number: PCT/US9917/252 (87) International publication number: WO 0006/716 (10.02.2000 Gazette 2000/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.07.1998 US 123929 (71) Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Baltimore, MD 21205 (US)	(72) Inventors: LEE, Se-Jin Baltimore, MD 21209 (US) MCPHERRON, Alexandra, C. Baltimore, MD 21201 (US) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)