(19)

(11)

EP 1 100 889 A1

(12)

(43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99935624.9 (22) Date of filing: 16.07.1999

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/87, C12N 15/88, C07H 21/04 (86) International application number: PCT/US9916/107 (87) International publication number: WO 0004/139 (27.01.2000 Gazette 2000/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.07.1998 US 93231 P (71) Applicant: Mirus Corporation Madison, WI 53711 (US)	(72) Inventor: WOLFF, Jon, A. Madison, WI 53705 (US) (74) Representative: Van Someren, Petronella F. H. M. et al Arnold & Siedsma,Advocaten en Octrooigemachtigden,Sweelinckplein 1 2517 GK Den Haag 2517 GK Den Haag (NL)