(19)

(11)

EP 1 100 899 A2

(12)

(88) Date of publication A3: 15.06.2000 (43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99932391.8 (22) Date of filing: 12.07.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 19/00, C07K 17/00, C12N 15/56, C12N 15/86, C12N 1/21, C12N 5/10, C07K 16/28, G01N 33/68, A01K 67/027 (86) International application number: PCT/US9915/710 (87) International publication number: WO 0006/726 (10.02.2000 Gazette 2000/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.07.1998 US 123168 (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)	(72) Inventors: SHUTTER, John, R. Moorpark, CA 93021 (US) STARK, Kevin, L. Thousand Oaks, CA 91362 (US) (74) Representative: Richardson, Kate  Forrester & Boehmert,Franz-Joseph Strasse 38 80801 München 80801 München (DE)