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(11)

EP 1 100 907 A2

(12)

(88) Date of publication A3: 04.05.2000 (43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99938859.8 (22) Date of filing: 30.07.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, A61K 38/16, C12N 15/11, C12Q 1/68, C12N 15/62, G01N 33/566 (86) International application number: PCT/US9917/167 (87) International publication number: WO 0006/730 (10.02.2000 Gazette 2000/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.07.1998 US 155185 P 04.08.1998 US 160081 P 19.08.1998 US 155228 P (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto, CA 94304 (US)

(72) Inventors: BANDMAN, Olga Mountain View, CA 94043 (US) TANG, Y., Tom San Jose, CA 95118 (US) YUE, Henry Sunnyvale, CA 94087 (US) CORLEY, Neil, C. Mountain View, CA 94040 (US) GUEGLER, Karl, J. Menlo Park, CA 94025 (US) AZIMZAI, Yalda Hayward, CA 94545 (US) PATTERSON, Chandra Menlo Park, CA 94025 (US) LAL, Preeti Santa Clara, CA 95054 (US) BAUGHN, Mariah, R. San Leandro, CA 94577 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)