(19)

(11)

EP 1 100 914 A2

(12)

(88) Date of publication A3: 29.06.2000 (43) Date of publication: 23.05.2001 Bulletin 2001/21 (21) Application number: 99944319.5 (22) Date of filing: 02.08.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/86, C12N 5/10, C07K 14/47, C07K 16/18, A61K 31/70, A61K 48/00, G01N 33/53 (86) International application number: PCT/EP9905/566 (87) International publication number: WO 0008/145 (17.02.2000 Gazette 2000/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.08.1998 US 128310 (71) Applicants: Novartis AG 4058 Basel (CH) BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE CY  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. 1230 Wien (AT) AT	(72) Inventors: COOKE, Michael, Paul Del Mar, CA 92014 (US) HOLNESS, Claire, Louise Palo Alto, CA 94306 (US) SIRENKO, Oksana Ivanivna Belmont, CA 94002 (US) (74) Representative: Becker, Konrad  Novartis AGCorporate Intellectual PropertyPatent- und Markenabteilung 4002 Basel 4002 Basel (CH)