(19)

(11)

EP 1 102 846 A1

(12)

(43) Date of publication: 30.05.2001 Bulletin 2001/22 (21) Application number: 99940860.2 (22) Date of filing: 03.08.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/62, G01N 33/50, C07K 16/18 (86) International application number: PCT/US9917/552 (87) International publication number: WO 0008/154 (17.02.2000 Gazette 2000/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.08.1998 US 128372 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Granite Falls, WA 98252 (US) CHANDRASEKHER, Yasmin Mercer Island, WA 98040 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)