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(11)

EP 1 104 304 A1

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(43) Date of publication: 06.06.2001 Bulletin 2001/23 (21) Application number: 99916118.5 (22) Date of filing: 07.04.1999

(51) International Patent Classification (IPC)7: A61K 38/00, C07C 279/18, C07C 279/20 (86) International application number: PCT/US9904/296 (87) International publication number: WO 0009/143 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 13.08.1998 US 96442 P (71) Applicant: G.D. SEARLE & CO. Chicago, IL 60680-5110 (US)	(72) Inventors: FOK, Kam, F. St. Louis, MO 63146 (US) TJOENG, Foe, S. Manchester, MO 63021 (US) (74) Representative: Weisert, Annekäte, Dipl.-Ing. Dr.-Ing.  PatentanwälteKraus & WeisertThomas-Wimmer-Ring 15 80539 München 80539 München (DE)