(19)

(11)

EP 1 105 112 A2

(12)

(88) Date of publication A3: 18.05.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99942108.4 (22) Date of filing: 12.08.1999

(51) International Patent Classification (IPC)7: A61K 31/00, A61K 31/4439, A61K 31/401, A61K 31/40, A61K 31/445, A61K 31/426, A61K 31/4025, A61P 27/02, A61P 25/28, A61P 27/12 (86) International application number: PCT/US9918/241 (87) International publication number: WO 0009/108 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.08.1998 US 134422 (71) Applicant: GPI NIL Holdings, Inc. Wilmington, DE 19899 (US)	(72) Inventors: ROSS, Douglas, T. North Wales, PA 19454 (US) SAUER, Hansjorg Silver Spring, MD 20901 (US) HAMILTON, Gregory, S. Catonsville, MD 21228 (US) STEINER, Joseph, P. Finksburg, MD 21048 (US) (74) Representative: Evens, Paul Jonathan et al Maguire Boss,5 Crown Street St. Ives,Cambridge PE27 5EB St. Ives,Cambridge PE27 5EB (GB)