(19)

(11)

EP 1 105 144 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 98943227.3 (22) Date of filing: 18.08.1998

(51) International Patent Classification (IPC)7: A61K 35/78 (86) International application number: PCT/US9817/074 (87) International publication number: WO 0010/586 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicants: Diaz, Jose A. Coconut Grove, FL 33133 (US) Naranjo, Eduardo M. Coconut Grove, FL 33133 (US)	(72) Inventors: Diaz, Jose A. Coconut Grove, FL 33133 (US) Naranjo, Eduardo M. Coconut Grove, FL 33133 (US) (74) Representative: Wagner, Karl H., Dipl.-Ing.  Wagner & Geyer,Patentanwälte,Gewürzmühlstrasse 5 80538 München 80538 München (DE)